Towards the proteome of the rhodopsin-bearing post-Golgi compartment of retinal photoreceptor cells

2000 ◽  
Vol 21 (16) ◽  
pp. 3460-3469 ◽  
Author(s):  
Valerie Morel ◽  
Ramina Poschet ◽  
Valerie Traverso ◽  
Dusanka Deretic
Keyword(s):  
Photoreceptor Cells ◽  
Retinal Photoreceptor ◽  
Golgi Compartment

Spindle shaped bodies in foveolar cones of the baboon retina

1989 ◽  
Vol 47 ◽  
pp. 960-961
Author(s):  
W. Krebs ◽  
I. Krebs
Keyword(s):  
Cross Sections ◽  
Inclusion Bodies ◽  
Photoreceptor Cells ◽  
Papio Anubis ◽  
Retinal Photoreceptor ◽  
Age Related ◽  
Cone Cells ◽  
Membrane Bound ◽  
Oriented Parallel ◽  
Shaped Inclusion

Various inclusion bodies occur in vertebrate retinal photoreceptor cells. Most of them are membrane bound and associated with phagocytosis or they are age related residual bodies. We found an additional inclusion body in foveal cone cells of the baboon (Papio anubis) retina.The eyes of a 15 year old baboon were fixed by immersion in cacodylate buffered glutaraldehyde (2%)/formaldehyde (2%) as described in detail elsewhere . Pieces of retina from various locations, including the fovea, were embedded in epoxy resin such that radial or tangential sections could be cut.Spindle shaped inclusion bodies were found in the cytoplasm of only foveal cones. They were abundant in the inner segments, close to the external limiting membrane (Fig. 1). But they also occurred in the outer fibers, the perikarya, and the inner fibers (Henle’s fibers) of the cone cells. The bodies were between 0.5 and 2 μm long. Their central diameter was 0.2 to 0. 3 μm. They always were oriented parallel to the long axis of the cone cells. In longitudinal sections (Figs. 2,3) they seemed to have a fibrous skeleton that, in cross sections, turned out to consist of plate-like (Fig.4) and tubular profiles (Fig. 5).

scholarly journals Long noncoding RNA U90926 is crucial for herpes simplex virus type 1 proliferation in murine retinal photoreceptor cells

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Shintaro Shirahama ◽  
Rena Onoguchi-Mizutani ◽  
Kentaro Kawata ◽  
Kenzui Taniue ◽  
Atsuko Miki ◽  
...  
Keyword(s):  
Herpes Simplex Virus ◽  
Herpes Simplex ◽  
Post Infection ◽  
Noncoding Rna ◽  
Survival Rates ◽  
Photoreceptor Cells ◽  
Sequencing Analysis ◽  
Retinal Photoreceptor ◽  
Simplex Virus ◽  
Hsv 1

Abstract Long non-coding RNAs (lncRNAs) play vital roles in the pathogenesis of infectious diseases, but the role of lncRNAs in herpes simplex virus 1 (HSV-1) infection remains unknown. Using RNA sequencing analysis, we explored lncRNAs that were highly expressed in murine retinal photoreceptor cell-derived 661W cells infected with HSV-1. U90926 RNA (522 nucleotides) was the most upregulated lncRNA detected post HSV-1 infection. The level of U90926 RNA was continuously increased post HSV-1 infection, reaching a 100-fold increase at 24 h. Cellular fractionation showed that U90926 RNA was located in the nucleus post HSV-1 infection. Downregulation of U90926 expression by RNA interference markedly suppressed HSV-1 DNA replication (80% reduction at 12 h post infection) and HSV-1 proliferation (93% reduction at 12 h post infection) in 661W cells. The survival rates of U90926-knockdown cells were significantly increased compared to those of control cells (81% and 21%, respectively; p < 0.0001). Thus, lncRNA U90926 is crucial for HSV-1 proliferation in retinal photoreceptor cells and consequently leads to host cell death by promoting HSV-1 proliferation.

Evaluation of viability of retinal photoreceptor cells by using their endogenous electrical field

2002 ◽  
Vol 56 (1-2) ◽  
pp. 219-221 ◽  
Author(s):  
Eugenia Kovács ◽  
Roxana Pologea-Moraru ◽  
Basarab Gabriel Hosu
Keyword(s):  
Photoreceptor Cells ◽  
Electrical Field ◽  
Retinal Photoreceptor

scholarly journals N-Acetylserotonin

2012 ◽  
Vol 18 (6) ◽  
pp. 645-653 ◽  
Author(s):  
Gianluca Tosini ◽  
Keqiang Ye ◽  
P. Michael Iuvone
Keyword(s):  
Neurotrophic Factor ◽  
Antidepressant Activity ◽  
Photoreceptor Cells ◽  
Distribution Patterns ◽  
Brain Distribution ◽  
Negative Effects ◽  
Independent Manner ◽  
Trkb Receptor ◽  
Naturally Occurring ◽  
Retinal Photoreceptor

N-Acetylserotonin (NAS) is a naturally occurring chemical intermediate in biosynthesis of melatonin. Previous studies have shown that NAS has different brain distribution patterns from those of serotonin and melatonin, suggesting that NAS might have functions other than as a precursor or metabolite of melatonin. Indeed, several studies have now shown that NAS may play an important role in mood regulation and may have antidepressant activity. Additional studies have shown that NAS stimulates proliferation of neuroprogenitor cells and prevents some of the negative effects of sleep deprivation. It is believed that the antidepressant and neurotrophic actions of NAS are due at least in part to the capability on this molecule to activate the TrkB receptor in a brain-derived neurotrophic factor–independent manner. Emerging evidence also indicates that NAS and its derivatives have neuroprotective properties and protect retinal photoreceptor cells from light-induced degeneration. In this review, the authors discuss the literature about this exciting and underappreciated molecule.

scholarly journals Temporal coupling of cyclic AMP and Ca2+/calmodulin-stimulated adenylyl cyclase to the circadian clock in chick retinal photoreceptor cells

2006 ◽  
Vol 99 (4) ◽  
pp. 1142-1150 ◽  
Author(s):  
Shyam S. Chaurasia ◽  
Rashidul Haque ◽  
Nikita Pozdeyev ◽  
Chad R. Jackson ◽  
P. Michael Iuvone
Keyword(s):  
Cyclic Amp ◽  
Circadian Clock ◽  
Adenylyl Cyclase ◽  
Photoreceptor Cells ◽  
Retinal Photoreceptor ◽  
Temporal Coupling
Sign in / Sign up

Export Citation Format

Share Document